反应详情

A mixture of ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate (1.1 g), iron powder (1.1 g) and ammonium chloride (0.11 g) in ethanol (10 ml) and water (5 ml) was stirred and refluxed for 1 hour. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed with water, dried and evaporated to give crystals of ethyl 4-amino-3-(2,4-difluorophenylthio)benzoate (1.1 g).

1. temperaturerefluxed for 1 hour
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwashed with water
6. customdried
7. customevaporated