反应详情

A mixture of N-methyl-3-(2,4-difluorophenylthio)-4-nitrobenzamide (0.68 g), iron powder (0.68 g) and ammonium chloride (68 mg) in ethanol (8 ml) and water (4 ml) was stirred and refluxed for 2 hours. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate, washed with water, dried and evaporated to give pale yellow crystals of N-methyl-4-amino-3-(2,4-difluorophenylthio)benzamide (0.78 g).

1. temperaturerefluxed for 2 hours
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwashed with water
6. customdried
7. customevaporated