反应详情

A mixture of 3'-(2,4-difluorophenylthio)-4'-nitroacetophenone (2.3 g), iron powder (2 g), and ammonium chloride (0.2 g) in ethanol (20 ml) and water (10 ml) was refluxed with stirring for an hour. The insoluble was filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed with water, dried over magnesium sulfate, and concentrated to give crystals of 4'-amino-3'-(2,4-difluorophenylthio)acetophenone (2.0 g).

1. temperaturewas refluxed
2. filtrationThe insoluble was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated