Hydrochloric Acid → HCID 19817727, compound

Participants

Reaction Steps

A mixture of 2-[3-(2,4-difluorophenylamino)-4-nitrophenyl]-2-methyl-1,3-dioxolane (10 g) and 3N-hydrochloric acid (20 ml) in acetone (40 ml) was stirred overnight at room temperature. The mixture was concentrated under reduced pressure. To the residue were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate. The organic layer was dried and concentrated to give an oil of 3'-(2,4-difluorophenylamino)-4'-nitroacetophenone (8.5 g).

Provenance & Evidence