Hydrochloric Acid → HCID 19817727, compound

HRID 1087195Notes

Reaction equation

HRID 1087195 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[C:12]([C:19]2([CH3:24])OCC[O:20]2)[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17].Cl>CC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[C:12]([C:19](=[O:20])[CH3:24])[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 103149282-[3-(2,4-Difluorophenylamino)-4-nitrophenyl]-2-methyl-1,3-dioxolane

Product 1

HCID 19817727HCID 19817727, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 2-[3-(2,4-difluorophenylamino)-4-nitrophenyl]-2-methyl-1,3-dioxolane (10 g) and 3N-hydrochloric acid (20 ml) in acetone (40 ml) was stirred overnight at room temperature. The mixture was concentrated under reduced pressure. To the residue were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate. The organic layer was dried and concentrated to give an oil of 3'-(2,4-difluorophenylamino)-4'-nitroacetophenone (8.5 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionTo the residue were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate
  3. customThe organic layer was dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-247ea07f6382438bb5e69febe8e68cc6
Source dataset
uspto-grants-1991_07
Patent number
US05034417

Reaction notes

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