Hydrochloric Acid → HCID 10333588, compound

Participants

Reaction Steps

A mixture of 4-acetyl-2-(2,4-difluorobenzoyl)acetanilide (4.2 g) and concentrated hydrochloric acid (10 ml) in ethanol (30 ml) was refluxed for 5 hours. The mixture was concentrated and the residue was dissolved in ethyl acetate (100 ml). The solution obtained was washed with an aqueous solution of sodium bicarbonate, dried and evaporated to give crystals of 5-acetyl-2-amino-2',4'-difluorobenzophenone (3.6 g).

Provenance & Evidence