Hydrochloric Acid → HCID 10333588, compound

HRID 1087198Notes

Reaction equation

HRID 1087198 reaction equation
C([C:4]1([F:23])[CH:21]=[CH:20][C:7]([C:8]([CH2:10][C:11]([NH:13]C2C=CC=CC=2)=O)=[O:9])=[C:6]([F:22])[CH2:5]1)(=O)C.Cl>C(O)C>[C:8]([C:7]1[CH:6]=[CH:5][C:11]([NH2:13])=[C:10]([CH:20]=1)[C:8]([C:7]1[CH:20]=[CH:21][C:4]([F:23])=[CH:5][C:6]=1[F:22])=[O:9])(=[O:9])[CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86744932HCID 86744932, compound

Product 1

HCID 10333588HCID 10333588, compoundYield 198.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-acetyl-2-(2,4-difluorobenzoyl)acetanilide (4.2 g) and concentrated hydrochloric acid (10 ml) in ethanol (30 ml) was refluxed for 5 hours. The mixture was concentrated and the residue was dissolved in ethyl acetate (100 ml). The solution obtained was washed with an aqueous solution of sodium bicarbonate, dried and evaporated to give crystals of 5-acetyl-2-amino-2',4'-difluorobenzophenone (3.6 g).

Workup

  1. temperaturewas refluxed for 5 hours
  2. concentrationThe mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate (100 ml)
  4. customThe solution obtained
  5. washwas washed with an aqueous solution of sodium bicarbonate
  6. customdried
  7. customevaporated

Sources & evidence

ORD record
ord-894ff50afe2d41a5b9de93761cc227b6
Source dataset
uspto-grants-1991_07
Patent number
US05034417

Reaction notes

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