反应详情

A mixture of 4'-amino-3'-(2,4-difluorophenylthio)acetophenone (2 g), pyridine (0.623 g) and iodobenzene dichloride (2.7 g) in tetrahydrofuran (20 ml) was stirred for 1.5 hours at 0° to 5° C. The mixture was concentrated to dryness. The residue was dissolved in ethyl acetate, washed with water and an aqueous solution of sodium hydrogensulfite successively, dried, and evaporated. The solid residue was washed with a mixture of hexane and ethanol to give 4'-amino-3'-chloro-5'-(2,4-difluorophenylthio)acetophenone (1.7 g).

1. concentrationThe mixture was concentrated to dryness
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with water
4. dry with materialan aqueous solution of sodium hydrogensulfite successively, dried
5. customevaporated
6. washThe solid residue was washed with a mixture of hexane and ethanol