HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2'-(2,4-Difluorophenylthio)-4'-[1-(methoxyimino)ethyl]methanesulfonanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | Methanesulfonamide, N-[4-acetyl-2-[(2,4-difluorophenyl)thio]phenyl]- | HCID 10450972 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2'-(2,4-Difluorophenylthio)-4'-[1-(methoxyimino)ethyl]methanesulfonanilide | HCID 54454246 | 82.3% |
Reaction Steps
A mixture of 4'-acetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide (0.9 g), methoxylamine hydrochloride (0.21 g) and pyridine (0.2 g) in ethanol (15 ml) was refluxed for 4 hours. The mixture was concentrated under reduced pressure, and the residue was triturated with water to give a powder. The powder was recrystallized from ethanol to give 2'-(2,4-difluorophenylthio)-4'-[1-(methoxyimino)ethyl]methanesulfonanilide (0.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034417 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-0d6e7061eafa41a7aff91312826b9946 |
| Source note | uspto-grants-1991_07 |