反应详情

A mixture of 4'-acetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide (0.9 g), methoxylamine hydrochloride (0.21 g) and pyridine (0.2 g) in ethanol (15 ml) was refluxed for 4 hours. The mixture was concentrated under reduced pressure, and the residue was triturated with water to give a powder. The powder was recrystallized from ethanol to give 2'-(2,4-difluorophenylthio)-4'-[1-(methoxyimino)ethyl]methanesulfonanilide (0.8 g).

1. temperaturewas refluxed for 4 hours
2. concentrationThe mixture was concentrated under reduced pressure
3. customthe residue was triturated with water
4. customto give a powder
5. customThe powder was recrystallized from ethanol