Thiourea → 4'-(2-Amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide

HRID 1087216Notes

Reaction equation

HRID 1087216 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:15]=[CH:14][C:8]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])=[C:7]([S:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[F:24])[CH:6]=1)=O.[NH2:25][C:26]([NH2:28])=[S:27]>CO>[BrH:1].[NH2:28][C:26]1[S:27][CH:2]=[C:3]([C:5]2[CH:15]=[CH:14][C:8]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])=[C:7]([S:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=3[F:24])[CH:6]=2)[N:25]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 149730324'-Bromoacetyl-2'(2,4-difluorophenylthio)methanesulfonanilide

Product 1

HCID 198177534'-(2-Amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4'-bromoacetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide and thiourea (0.58 g) in methanol (15 ml) was refluxed for 1 hour, and then cooled. The precipitates were filtered, washed with ethanol and dried to give crystals of 4'-(2-amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide (1.9 g).

Workup

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. filtrationThe precipitates were filtered
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-f1fd160d04824050b73ab0f8dcd52cbe
Source dataset
uspto-grants-1991_07
Patent number
US05034417

Reaction notes

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