反应详情

A mixture of 4'-bromoacetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide and thiourea (0.58 g) in methanol (15 ml) was refluxed for 1 hour, and then cooled. The precipitates were filtered, washed with ethanol and dried to give crystals of 4'-(2-amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide (1.9 g).

1. temperaturewas refluxed for 1 hour
2. temperaturecooled
3. filtrationThe precipitates were filtered
4. washwashed with ethanol
5. customdried