HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → 4'-(2-Amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 4'-Bromoacetyl-2'(2,4-difluorophenylthio)methanesulfonanilide | HCID 14973032 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4'-(2-Amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide | HCID 19817753 | — |
Reaction Steps
A mixture of 4'-bromoacetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide and thiourea (0.58 g) in methanol (15 ml) was refluxed for 1 hour, and then cooled. The precipitates were filtered, washed with ethanol and dried to give crystals of 4'-(2-amino-4-thiazolyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide hydrobromide (1.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034417 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-f1fd160d04824050b73ab0f8dcd52cbe |
| Source note | uspto-grants-1991_07 |