Nitric Acid → HCID 19817740, compound

HRID 1087217Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[CH:6][C:7]([S:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[F:23])=[C:8]([CH:14]=1)[NH:9][S:10]([CH3:13])(=[O:12])=[O:11])(=[O:3])[CH3:2].[N+:24]([O-])([OH:26])=[O:25]>C(O)(=O)C>[C:1]([C:4]1[C:5]([N+:24]([O-:26])=[O:25])=[CH:6][C:7]([S:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[F:23])=[C:8]([CH:14]=1)[NH:9][S:10]([CH3:13])(=[O:12])=[O:11])(=[O:3])[CH3:2]

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of 5'-acetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide (1 g) and nitric acid (248 mg) in acetic acid (5 ml) was stirred at 80° C. for 1 hour. The reaction mixture was evaporated to dryness. The residue was washed with ethanol to give yellow crystals of 5'-acetyl-2'-(2,4-difluorophenylthio)-4'-nitromethanesulfonanilide (0.96 g).

Workup

customThe reaction mixture was evaporated to dryness
washThe residue was washed with ethanol

Sources & evidence

ORD record: ord-ad67e8af750c4b49a2d204677b4e2cae
Source dataset: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05034417

Reaction notes

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