反应详情

A mixture of 2-amino-5-nitro-2',4'-difluorobenzophenone (5.1 g) and methanesulfonyl chloride (14 ml) in pyridine (40 ml) was stirred at room temperature overnight. The mixture was poured into cold 3N hydrochloric acid (200 ml). The insoluble was filtered and dissolved in a mixture of pyridine (20 ml), ethanol (5 ml) and 5% sodium hydroxide (50 ml). The solution was stirred overnight and washed with toluene. The aqueous layer was acidified with hydrochloric acid and the precipitates were filtered to give brown crystals of 2'-(2,4-difluorobenzoyl)-4'-nitromethanesulfonanilide (5.7 g).

1. filtrationThe insoluble was filtered
2. dissolutiondissolved in a mixture of pyridine (20 ml), ethanol (5 ml) and 5% sodium hydroxide (50 ml)
3. stirringThe solution was stirred overnight
4. washwashed with toluene
5. filtrationthe precipitates were filtered