反应详情

A mixture of 2'-(2,4-difluoro-α-hydroxybenzyl)-4'-nitromethanesulfonanilide (5.3 g), 10% palladium on carbon (1 g) and acetic acid (6 ml) in methanol (60 ml) was shaken under hydrogen atmosphere for 9 hours. The mixture was filtered and the filtrate was evaporated. The residue was dissolved in ethyl acetate, washed with a saturated solution of sodium bicarbonate, dried, and evaporated. The sirupy residue was recrystallized from ethanol to give crystals of 4'-amino-2'-(2,4-difluorobenzyl)methanesulfonanilide (3.2 g).

1. filtrationThe mixture was filtered
2. customthe filtrate was evaporated
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with a saturated solution of sodium bicarbonate
5. customdried
6. customevaporated
7. customThe sirupy residue was recrystallized from ethanol