Acetic Acid → HCID 19817699, compound

Participants

Reaction Steps

A mixture of 2'-(2,4-difluoro-α-hydroxybenzyl)-4'-nitromethanesulfonanilide (5.3 g), 10% palladium on carbon (1 g) and acetic acid (6 ml) in methanol (60 ml) was shaken under hydrogen atmosphere for 9 hours. The mixture was filtered and the filtrate was evaporated. The residue was dissolved in ethyl acetate, washed with a saturated solution of sodium bicarbonate, dried, and evaporated. The sirupy residue was recrystallized from ethanol to give crystals of 4'-amino-2'-(2,4-difluorobenzyl)methanesulfonanilide (3.2 g).

Provenance & Evidence