HCID 10856068, compound → HCID 14095404, compound

Temperature

60 °C

Methy 2,6-dideoxy-2-fluoro-α-L-talopyranoside (21 mg) as prepared in Example 2 (4) given hereinbefore was dissolved in 1 ml of a mixture of 3N HCl-75% trifluoroacetic acid-water (the concentration of HCl in the whole mixture was 3N), and the resulting solution was heated at 60° C. for 1.5 hours to effect the hydrolysis. The reaction solution was then concentrated under reduced pressure to a smaller volume and the concentrated solution was admixed with a volume of water and azeotropically distilled. The residual solution was then concentrated to dryness to give 18 mg (93%) of the titled compound as a colorless solid. Specific rotation [α]D25 -21° (c 1, dioxane-water, 4:1).

1. customthe hydrolysis
2. concentrationThe reaction solution was then concentrated under reduced pressure to a smaller volume
3. distillationazeotropically distilled
4. concentrationThe residual solution was then concentrated to dryness

ORD record

ord-6f23eda3003f488c90decf8897128938

Source dataset

uspto-grants-1991_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05034517