Methanol → HCID 178501589, compound

HRID 1087288Notes

Reaction equation

HRID 1087288 reaction equation
Cl.Cl.[NH2:3][CH:4]([CH:8]([C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)[CH3:9])[C:5]([OH:7])=[O:6].[CH3:15]O>>[NH2:3][CH:4]([CH:8]([C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)[CH3:9])[C:5]([O:7][CH3:15])=[O:6]

Participants

3

Reactant 2

HCID 887MethanolHCID 178437197HCID 178437197, compound

Product 1

HCID 178501589HCID 178501589, compound

Procedure

9.40 g (38.9 mmol) of 2-amino-3-(1H-imidazol-4-yl)butyric acid dihydrochloride are solved in 100 ml methanol. Dry HCl-gas is bubbled through the solution while heating under reflux for 4 hours. After cooling the excess hydrochloric acid is removed by evaporation in vacuo. Yield: 9.8 g (98%) methyl 2-amino-3-(1H-imidazol-4-yl)butyrate hydrochloride as an amorphous solid.

Workup

  1. customDry HCl-gas is bubbled through the solution
  2. temperaturewhile heating
  3. temperatureunder reflux for 4 hours
  4. temperatureAfter cooling the excess hydrochloric acid
  5. customis removed by evaporation in vacuo

Sources & evidence

ORD record
ord-c3cdcb7d33104f3cbaf69625228fe64d
Source dataset
uspto-grants-1991_07
Patent number
US05034539

Reaction notes

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