反应详情

To an ice-cooled solution of 1.15 g N-(morpholinocarbonyl)-L-phenylalanine-S-methyl-L-cysteine methyl ester in 30 mL water and 60 mL methanol was added 3.5 g potassium carbonate. The resulting mixture was stirred at 0° for 15 min. and at ambient temperature for 4 h. The solution was concentrated in vacuo to an aqueous solution, which was acidified with conc. hydrochloric acid and extracted 3×50 mL methylene chloride. The combined extracts were dried over magnesium sulfate, filtered and concentrated in vacuo to afford 1.0 g (89%) of the crude acid.

1. concentrationThe solution was concentrated in vacuo to an aqueous solution, which
2. extractionextracted 3×50 mL methylene chloride
3. dry with materialThe combined extracts were dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo