反应详情

To trifluoroacetic acid (100 ml) under argon and cooled to 0° C., was added methyl 3-mercaptopropanoate (0.5 ml, 4.5 mmoles). The mixture was stirred for 10 minutes, after which the ice bath was removed. Methyl 2-methoxy-3-hydroxy-3-[2-(8-phenyloctyl)phenyl]propanoate (1.5 g, 4 mmoles) was added and the mixture stirred for 18 hours. The reaction mixture was evaporated and diluted in methylene chloride. The organic layer was washed with 10% sodium hydroxide (ice cold) followed by ice water. The organic layer was dried over magnesium sulfate, filtered and evaporated. Flash chromatography on silica gel provided the desired product.

1. customafter which the ice bath was removed
2. stirringthe mixture stirred for 18 hours
3. customThe reaction mixture was evaporated
4. additiondiluted in methylene chloride
5. washThe organic layer was washed with 10% sodium hydroxide (ice cold)
6. dry with materialThe organic layer was dried over magnesium sulfate
7. filtrationfiltered
8. customevaporated