Ethanolamine → HCID 54522853, compound

Participants

Reaction Steps

A mixture of 14.5 g of (Intermediate A) and 5.3 g of ethanolamine was reacted under reduced pressure of 30 mmHg at 120° C. for 2 hours. The reaction mixture was cooled to room temperature and dissolved with an additional 30 ml of methanol. 300 ml of isopropanol was further added to the mixture to precipitate crystals. The crystals were filtered off, washed with isopropanol and dried to obtain 13 g (Yield: 86.5%) of 3-(2-hydroxyethylcarbamoyl)-1-(2-sulfobenzyl)pyrazolin-5-one.

Provenance & Evidence