Ethanolamine → HCID 54522853, compound

HRID 1087368Notes

Reaction equation

HRID 1087368 reaction equation
C(O[C:4]([C:6]1[NH:7][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([OH:22])(=[O:21])=[O:20])[C:9](=[O:11])[CH:10]=1)=[O:5])C.[CH2:23]([CH2:25][NH2:26])[OH:24].CO>C(O)(C)C>[OH:24][CH2:23][CH2:25][NH:26][C:4]([C:6]1[NH:7][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([OH:22])(=[O:20])=[O:21])[C:9](=[O:11])[CH:10]=1)=[O:5]

Participants

5

Reactant 3

HCID 700EthanolamineHCID 887MethanolHCID 53910740HCID 53910740, compound

Product 1

HCID 54522853HCID 54522853, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 14.5 g of (Intermediate A) and 5.3 g of ethanolamine was reacted under reduced pressure of 30 mmHg at 120° C. for 2 hours. The reaction mixture was cooled to room temperature and dissolved with an additional 30 ml of methanol. 300 ml of isopropanol was further added to the mixture to precipitate crystals. The crystals were filtered off, washed with isopropanol and dried to obtain 13 g (Yield: 86.5%) of 3-(2-hydroxyethylcarbamoyl)-1-(2-sulfobenzyl)pyrazolin-5-one.

Workup

  1. customwas reacted under reduced pressure of 30 mmHg at 120° C. for 2 hours
  2. customto precipitate crystals
  3. filtrationThe crystals were filtered off
  4. washwashed with isopropanol
  5. customdried

Sources & evidence

ORD record
ord-7cb67990c201480a9facb2e328b15ff8
Source dataset
uspto-grants-1991_07
Patent number
US05035985

Reaction notes

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