Dimethyl Sulfate → HCID 19816891, compound

HRID 1087376Notes

Reaction equation

HRID 1087376 reaction equation
[CH3:1][C:2]1([CH3:22])[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][NH:12][C:11](=[O:15])[CH:10]=2)[C:5]2[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:4]=2[O:3]1.[C:23]([O-])([O-])=O.[K+].[K+].S(OC)(OC)(=O)=O>CC(C)=O>[CH3:1][C:2]1([CH3:22])[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]([CH3:23])[C:11](=[O:15])[CH:10]=2)[C:5]2[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 19816866HCID 19816866, compound

Product 1

HCID 19816891HCID 19816891, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 295 mg of 2,2-dimethyl-4-(2-oxo-1,2-dihydro-4-pyridyloxy)-6-cyano-2H-1,3-benzoxazine, 20 ml of acetone, 400 mg of K2CO3 and 0.2 ml of dimethyl sulfate is boiled for 2 hours. The mixture is filtered and subjected to customary work-up to give 2,2-dimethyl-4-(1-methyl-2-oxo-1,2-dihydro-4-pyridyloxy)-6-cyano-2H-1,3-benzoxazine.

Workup

  1. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-efe62f7fcf314d1f941f189941971816
Source dataset
uspto-grants-1991_07
Patent number
US05036068

Reaction notes

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