Hydrochloric Acid → HCID 14456701, compound

HRID 1087416Notes

Reaction equation

HRID 1087416 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11](Br)[C:12]([OH:14])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH2:16][C:17](N)=[S:18].Cl.S1(CCCC1)(=O)=[O:22]>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]2[S:18][C:17](=[O:22])[NH:16][C:12]2=[O:14])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2652713-(4-acetylphenyl)-2-bromopropanoic acidHCID 2723790Thiourea

Product 1

HCID 14456701HCID 14456701, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-(4-acetylphenyl)-2-bromopropanoic acid (87 g, 0.32 mol, prepared according to Cleland, Org. Synth. vol. 51, p. 1, 1971), and thiourea (48.7 g,) 0.64 mol) in sulfolane (100 mL) was heated to 105°-110° C. for 5 hours. To this mixture was added a 2N HCl solution (162 mL) and the resulting solution was heated to 105°-110° C. overnight. After cooling and diluting with water, present title product was collected, washed with water and dried (75 g, 94%); mp 171°-172° C.

Workup

  1. temperaturethe resulting solution was heated to 105°-110° C. overnight
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-e08da3d16dd04c448403bc5de407a67e
Source dataset
uspto-grants-1991_07
Patent number
US05036079

Reaction notes

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