2-Amino-6-methoxybenzothiazole → HCID 15662326, compound

HRID 1087459Notes

Reaction equation

HRID 1087459 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[C:13]([O:16][CH2:17][C:18](Cl)=[O:19])(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:16][CH2:17][C:18]([NH:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=2[N:6]=1)=[O:19])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 156302-Amino-6-methoxybenzothiazoleHCID 26297Acetoxyacetyl chloride

Product 1

HCID 15662326HCID 15662326, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-6-methoxybenzothiazole (12.0 g) is dissolved in pyridine (250 ml) and thereto is added dropwise acetoxyacetyl chloride (7.9 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water and then with diethyl ether, dried and recrystallized from ethanol to give the title compound (15.3 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-de3895ccaa1e403186b925daf66af856
Source dataset
uspto-grants-1991_07
Patent number
US05036086

Reaction notes

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