反应详情

温度

20 °C

A solution of 2-{3-[4-(4-fluorophenyl)-1-piperaziny]-2-hydroxypropyl}naphtho[1,8-cd]isothiazole 1,1-dioxide (4.41 g) in dimethylformamide (50 cc) is poured over 30 minutes into a mixture of sodium hydride (0.53 g) in a 50% dispersion in vaseline oil, and dimethylformamide (10 cc), under a current of argon, maintaining the temperature between 20° and 30° C. The reaction medium is stirred for 1 hour at temperature of about 20° C. and then methyl iodide (0.7 cc) is added over 10 minutes. Stirring is maintained for 15 hours at a temperature of about 20° C. The mixture is redissolved in distilled water (200 cc) and the organic phase is extracted with dichloromethane (4×100 cc), dried over anhydrous magnesium sulphate, filtered and concentrated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa). The residue is purified by flash-chromatography on a silica column, under a current of argon at medium pressure (0.5-1.5 bar) with ethyl acetate as eluant, and recrystallized from boiling acetonitrile (10 cc). 2-{3-[4-(4-Fluorophenyl)-1-piperazinyl]-2-methoxypropyl)naphtho[1,8-cd]isothiazole 1,1-dioxide (2.1 g) is obtained, m.p. 128° C.

1. temperatureunder a current of argon, maintaining the temperature between 20° and 30° C
2. stirringStirring
3. temperatureis maintained for 15 hours at a temperature of about 20° C
4. extractionthe organic phase is extracted with dichloromethane (4×100 cc)
5. dry with materialdried over anhydrous magnesium sulphate
6. filtrationfiltered
7. concentrationconcentrated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa)
8. customThe residue is purified by flash-chromatography on a silica column
9. customunder a current of argon at medium pressure (0.5-1.5 bar) with ethyl acetate as eluant, and recrystallized