Water → 1-Cyclohexyl-1-hydroxyl-1-phenylhex-5-yn-2-one

HRID 1087658Notes

Reaction equation

HRID 1087658 reaction equation
C[Si](C)(C)[O:3][C:4]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5](=[O:10])[CH2:6][CH2:7][C:8]#[CH:9].O>CO>[CH:17]1([C:4]([OH:3])([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:5](=[O:10])[CH2:6][CH2:7][C:8]#[CH:9])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 962WaterHCID 151058401-(Trimethylsilyloxy)-1-cyclohexyl-1-phenylhex-5-yn-2-one

Product 1

HCID 198172091-Cyclohexyl-1-hydroxyl-1-phenylhex-5-yn-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(Trimethylsilyloxy)-1-cyclohexyl-1-phenylhex-5-yn-2-one is dissolved in methanol containing 1% concentrated hydrochloric acid at 25° C. Water is added and the solution transferred to a separatory funnel. The solution is washed with ether and the ether layer dried over sodium sulfate. Upon evaporation of the ether under vacuum and vacuum distillation of the crude product a pale yellow oil is isolated.

Workup

  1. customthe solution transferred to a separatory funnel
  2. washThe solution is washed with ether
  3. dry with materialthe ether layer dried over sodium sulfate
  4. customUpon evaporation of the ether
  5. distillationunder vacuum and vacuum distillation of the crude product a pale yellow oil
  6. customis isolated

Sources & evidence

ORD record
ord-4d5443f021c2455da38259347e20ddc1
Source dataset
uspto-grants-1991_07
Patent number
US05036107

Reaction notes

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