HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Cyclohexyl-1-hydroxyl-1-phenylhex-5-yn-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(Trimethylsilyloxy)-1-cyclohexyl-1-phenylhex-5-yn-2-one | HCID 15105840 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Cyclohexyl-1-hydroxyl-1-phenylhex-5-yn-2-one | HCID 19817209 | — |
Reaction Steps
1-(Trimethylsilyloxy)-1-cyclohexyl-1-phenylhex-5-yn-2-one is dissolved in methanol containing 1% concentrated hydrochloric acid at 25° C. Water is added and the solution transferred to a separatory funnel. The solution is washed with ether and the ether layer dried over sodium sulfate. Upon evaporation of the ether under vacuum and vacuum distillation of the crude product a pale yellow oil is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05036107 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-4d5443f021c2455da38259347e20ddc1 |
| Source note | uspto-grants-1991_07 |