Einecs 211-027-4 → HCID 15718537, compound

HRID 1087719Notes

Reaction equation

HRID 1087719 reaction equation
C[O:2][C:3]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:4]=1[C:5]([C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1)=[O:6].[Cl-].[NH+]1C=CC=CC=1>>[OH:2][C:3]1[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:21])[F:22])=[CH:15][C:4]=1[C:5]([C:7]1[CH:8]=[CH:9][C:10]([C:11]#[N:12])=[CH:13][CH:14]=1)=[O:6]

Participants

3

Reactant 2

HCID 69401Einecs 211-027-4HCID 15718536HCID 15718536, compound

Product 1

HCID 15718537HCID 15718537, compoundYield 65%

Procedure

Following the procedure described in Preparation IVb and starting from 13.5 g (0.049 mol) of 4-(2-methoxy-5-trifluoromethylbenzoyl)benzonitrile and 31 g (0.27 mol) of pyridinium chloride, an amount of 8.4 g of the expected product (yield: 65%) is obtained after purification by flash chromatography using a hexane/ethyl acetate mixture (5/1 v/v) as the eluent.

Workup

  1. customdescribed in Preparation IVb

Sources & evidence

ORD record
ord-48f199cf1aaf4c0d82031f822262a938
Source dataset
uspto-grants-1990_10
Patent number
US04960758

Reaction notes

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