Hydrochloric Acid → HCID 86744237, compound

Participants

Reaction Steps

To a solution of 530 mg (1.82 mmol) of tert.butyl 3-(2-propynyloxy)-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepine-5-carboxylate (from Example 8) in ethyl acetate (10 ml) was added 10 ml of 1N solution of hydrochloric acid in ethyl acetate. The mixture was stirred at room temperature for 60 hours. The precipitate was collected and recrystallized from acetonitrile-ether yielding 267 mg (64%) of analytically pure title compound, MP 173°-175° C.

Provenance & Evidence