Hydrochloric Acid → HCID 86744237, compound

HRID 1087723Notes

Reaction equation

HRID 1087723 reaction equation
[CH2:1]([O:4][C:5]1[C:9]2[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][CH2:14][C:8]=2[O:7][N:6]=1)[C:2]#[CH:3].[ClH:22]>C(OCC)(=O)C>[ClH:22].[CH2:1]([O:4][C:5]1[C:9]2[CH2:10][NH:11][CH2:12][CH2:13][CH2:14][C:8]=2[O:7][N:6]=1)[C:2]#[CH:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10039974HCID 10039974, compound

Product 1

HCID 86744237HCID 86744237, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 530 mg (1.82 mmol) of tert.butyl 3-(2-propynyloxy)-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepine-5-carboxylate (from Example 8) in ethyl acetate (10 ml) was added 10 ml of 1N solution of hydrochloric acid in ethyl acetate. The mixture was stirred at room temperature for 60 hours. The precipitate was collected and recrystallized from acetonitrile-ether yielding 267 mg (64%) of analytically pure title compound, MP 173°-175° C.

Workup

  1. customThe precipitate was collected
  2. customrecrystallized from acetonitrile-ether yielding 267 mg (64%) of analytically pure title compound, MP 173°-175° C.

Sources & evidence

ORD record
ord-d5500c92c2ff4013be5099e93abce732
Source dataset
uspto-grants-1990_10
Patent number
US04960769

Reaction notes

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