Sodium borohydride → HCID 14556343, compound

HRID 1087744Notes

Reaction equation

HRID 1087744 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11](=[O:30])[CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=4)[CH2:16][CH2:15]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:31].[BH4-].[Na+]>CO>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH:11]([OH:30])[CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=4)[CH2:16][CH2:15]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:31]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 14556329HCID 14556329, compound

Product 1

HCID 14556343HCID 14556343, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.01 mole of 3-methyl-6-{3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-1-oxopropyl}benzoxazolinone is dissolved in 200 cm3 of methanol in a 250-cm3 flask equipped with a magnetic stirrer. 0.02 mole of sodium borohydride is added very slowly and with stirring. Stirring is maintained for 4 hours at room temperature. The reaction medium is evaporated on a water bath under vacuum. The residue is taken up with water and extracted several times with chloroform. The extracts are filtered and evaporated to dryness on a water bath under vacuum. The product is recrystallized in ethanol.

Workup

  1. customequipped with a magnetic stirrer
  2. stirringStirring
  3. customThe reaction medium is evaporated on a water bath under vacuum
  4. extractionextracted several times with chloroform
  5. filtrationThe extracts are filtered
  6. customevaporated to dryness on a water bath under vacuum
  7. customThe product is recrystallized in ethanol

Sources & evidence

ORD record
ord-f99dbe4ed98c4086b88a1ba2705e011f
Source dataset
uspto-grants-1990_10
Patent number
US04960778

Reaction notes

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