N,N-Dimethylethylenediamine → N-[2-(Dimethylamino)ethyl]-4-(3-methoxyphenyl)-1-piperazinecarboxamide

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 4.9 g (0.03 mole) of 1,1'-carbonyldiimidazole, 2.6 g (0.03 mole) of unsym-dimethylethylenediamine, and 5.8 g (0.03 mole) of 1-(3-methoxyphenyl)piperazine in a total of 200 ml of tetrahydrofuran gave an oil which solidified. After trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from cyclohexanebenzene to yield 4.7 g (51%) of the title compound as a white crystalline solid, m.p. 70°-72° C.

Provenance & Evidence