N,N-Dimethylethylenediamine → N-[2-(Dimethylamino)ethyl]-4-(3-methoxyphenyl)-1-piperazinecarboxamide

HRID 1087827ノート

反応式

HRID 1087827 の反応式
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[C:22](N1C=CN=C1)(N1C=CN=C1)=[O:23].CN(CCN)C.COC1C=C(N2CCNCC2)C=CC=1>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:23][CH3:22])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7]

参加物

6

反応物 4

HCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 81430N-(3-methoxyphenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

生成物 1

HCID 14763471N-[2-(Dimethylamino)ethyl]-4-(3-methoxyphenyl)-1-piperazinecarboxamide収率 51%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 4.9 g (0.03 mole) of 1,1'-carbonyldiimidazole, 2.6 g (0.03 mole) of unsym-dimethylethylenediamine, and 5.8 g (0.03 mole) of 1-(3-methoxyphenyl)piperazine in a total of 200 ml of tetrahydrofuran gave an oil which solidified. After trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from cyclohexanebenzene to yield 4.7 g (51%) of the title compound as a white crystalline solid, m.p. 70°-72° C.

後処理

  1. customThis compound was prepared
  2. customgave an oil which
  3. customAfter trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from cyclohexanebenzene

出典と根拠

ORDレコード
ord-c9a250abd06c424597ea0db5c1317a0a
出典データセット
uspto-grants-1990_10
特許番号
US04960776

反応ノート

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