HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 22163787, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-(Piperazin-1-yl)benzonitrile | HCID 2733995 | — |
| Reactant | N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide | HCID 14763463 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22163787 | HCID 22163787 | — |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.6 g (0.016 mole) of 1,1'-carbonyldiimidazole, 1.4 g (0.016 mole) of unsym-dimethylethylenediamine and 3.0 g (0.16 mole) of 1-(4-cyanophenyl)piperazine in a total volume of 250 ml of tetrahydrofuran gave an oil. The hydrochloride was formed in ethereal hydrogen chloride and the solid recrystallized from methanol-ethyl ether to give 1.2 g (20%) of the title compound as a white solid; m.p. 161°-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04960776 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-907ce80e62564222a5e20b24317d37ab |
| Source note | uspto-grants-1990_10 |