Hydrochloric Acid → HCID 22163787, compound

HRID 1087838Notes

Reaction equation

HRID 1087838 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[C:22](N1C=CN=C1)([N:24]1C=CN=C1)=O.CN(CCN)C.C(C1C=CC(N2CCNCC2)=CC=1)#N.[ClH:54]>O1CCCC1>[ClH:54].[C:22]([C:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][N:8]([C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])=[O:7])[CH2:9][CH2:10]2)=[CH:15][CH:16]=1)#[N:24]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 27339954-(Piperazin-1-yl)benzonitrileHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 22163787HCID 22163787, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.6 g (0.016 mole) of 1,1'-carbonyldiimidazole, 1.4 g (0.016 mole) of unsym-dimethylethylenediamine and 3.0 g (0.16 mole) of 1-(4-cyanophenyl)piperazine in a total volume of 250 ml of tetrahydrofuran gave an oil. The hydrochloride was formed in ethereal hydrogen chloride and the solid recrystallized from methanol-ethyl ether to give 1.2 g (20%) of the title compound as a white solid; m.p. 161°-164° C.

Workup

  1. customThis compound was prepared
  2. customgave an oil

Sources & evidence

ORD record
ord-907ce80e62564222a5e20b24317d37ab
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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