Piperidine → HCID 140353009, compound

HRID 1087881Notes

Reaction equation

HRID 1087881 reaction equation
[C:1]([NH:4][C:5]1[N:10]([O:11][C:12](=[O:14])[CH3:13])[C:9](=[NH:15])[N:8]=[C:7](OS(C2C=CC(C)=CC=2)(=O)=O)[CH:6]=1)(=[O:3])[CH3:2].[NH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>C(#N)C>[C:1]([NH:4][C:5]1[N:10]([O:11][C:12](=[O:14])[CH3:13])[C:9](=[NH:15])[N:8]=[C:7]([N:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 140351385[6-Acetamido-2-imino-4-(4-methylphenyl)sulfonyloxypyrimidin-1-yl] acetate

Product 1

HCID 140353009HCID 140353009, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture containing 0.5 g (0.0013 mole) of 6-acetamido-1-acetoxy-1,2-dihydro-2-imino-4-(4-toluenesulfonyloxy)pyrimidine in 20 ml of acetonitrile and 0.5 ml of piperidine is stirred at room temperature for 3 hours, then evaporated under reduced pressure. After adding 30 ml of ether to the residue, the crystalline precipitate is filtered, washed with ether and then with water, finally dried to give the aimed product in a yield of 0.24 g (64%), m.p.: 217°-218° C. (with decomposition).

Workup

  1. customevaporated under reduced pressure
  2. additionAfter adding 30 ml of ether to the residue
  3. filtrationthe crystalline precipitate is filtered
  4. washwashed with ether
  5. dry with materialwith water, finally dried

Sources & evidence

ORD record
ord-979f7f9cd3c84dc999de3737a757152e
Source dataset
uspto-grants-1990_10
Patent number
US04960888

Reaction notes

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