Aniline → HCID 70358983, compound

HRID 1087929Notes

Reaction equation

HRID 1087929 reaction equation
[CH3:1][NH:2][S:3]([C:6]1(Cl)[NH:10][C:9]([Cl:11])=[CH:8][S:7]1)(=[O:5])=[O:4].[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(Cl)Cl>[CH3:1][N:2]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:3]([C:6]1[S:7][CH:8]=[C:9]([Cl:11])[N:10]=1)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 6115AnilineHCID 22164323HCID 22164323, compound

Product 1

HCID 70358983HCID 70358983, compoundYield 15%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In analogy to Example 5, the N-methyl-2-N-phenylamino-4-chlorothiazole-sulphonamide was prepared by reacting N-methyl-2,4-dichlorothiazole-sulphonamide from Example 2 with aniline. Following chromatography on silica gel using methylene chloride as the eluent, the product having a melting point of 157-8° C. was obtained in 15% yield.

Workup

  1. customwas obtained in 15% yield

Sources & evidence

ORD record
ord-d39a86a9c6d34b69ac8ff5c15e88184a
Source dataset
uspto-grants-1990_10
Patent number
US04960899

Reaction notes

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