反应详情

温度

80 °C

A mixture of 3.60 g of 2-bromo-6-isopropenylpyridine, 2.91 g of N-chlorosuccinimide and 8 ml of benzene was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, n-hexane was added thereto to remove the insoluble matter through filtration. After distilling off the solvent, the residue was purified by silica gel column chromatography (eluted with n-hexane then n-hexane - ethyl acetate 20:1) to obtain 1.50 g of the objective compound.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. customto remove the insoluble matter
3. filtrationthrough filtration
4. distillationAfter distilling off the solvent
5. customthe residue was purified by silica gel column chromatography (
6. washeluted with n-hexane