Water → HCID 22164281, compound

HRID 1087948Notes

Reaction equation

HRID 1087948 reaction equation
C([O:4][CH2:5][C:6]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[N:23]=1)([OH:21])[CH2:7][N:8]([S:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([CH3:20])[CH:14]=1)(=[O:12])=[O:11])[CH3:9])(=O)C.C(N(CC)CC)C.O>CO>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([S:10]([N:8]([CH2:7][C:6]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[N:23]=2)([OH:21])[CH2:5][OH:4])[CH3:9])(=[O:11])=[O:12])=[CH:14][C:15]=1[CH3:20]

Participants

5

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 22164277HCID 22164277, compound

Product 1

HCID 22164281HCID 22164281, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.5 g of 1-acetoxy-3-[N-(4-chloro-3-methylbenzenesulfonyl)-N-methylamino]-2-(6-chloropyridin-2-yl)-2-hydroxypropane, 1 ml of triethylamine, 1 ml of water and 2 ml of methanol was stirred at room temperature for 4 hours. The reaction mixture was left to stand overnight, and the deposited crystals were filtered out and washed with water-containing methanol to obtain 1.17 g of the objective compound.

Workup

  1. waitThe reaction mixture was left
  2. waitto stand overnight
  3. filtrationthe deposited crystals were filtered out
  4. washwashed with water-
  5. additioncontaining methanol

Sources & evidence

ORD record
ord-55ad01871ae24163ab6e5c972bd147ae
Source dataset
uspto-grants-1990_10
Patent number
US04960897

Reaction notes

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