反应详情

温度

80 °C

To a mixture of 1.48 g of N-methyl-p-toluenesulfonamide, 1.0 g of 2-chloro-6-(l-chloromethylvinyl)pyridine (Compound No. I - 3), 0.05 g of tetra-n-butylammonium bromide and 15 ml of toluene, 4.3 g of an aqueous solution of 40% sodium hydroxide was added, and the whole mixture was stirred at 80° C. for 3 hours. The reaction mixture was subsequently washed with water and brine and dried over anhydrous potassium carbonate. After the solvent was distilled off, the residue was purified by silica gel column chromatography (eluted with benzene - ethyl acetate 15:1) to obtain 1.5 g of Compound No. 216 in Table 6.

1. washThe reaction mixture was subsequently washed with water and brine
2. dry with materialdried over anhydrous potassium carbonate
3. distillationAfter the solvent was distilled off
4. customthe residue was purified by silica gel column chromatography (eluted with benzene - ethyl acetate 15:1)