Hydrogen Bromide → 4',5,7-Trihydroxy-2-bromomethylisoflavone

HRID 1087961Notes

Reaction equation

HRID 1087961 reaction equation
C([O:4][C:5]1[CH:31]=[CH:30][C:8]([C:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][C:14]([O:24]C(=O)C)=[CH:15][C:16]=3[O:20]C(=O)C)[O:11][C:10]=2[CH2:28][Br:29])=[CH:7][CH:6]=1)(=O)C.Br>>[OH:4][C:5]1[CH:31]=[CH:30][C:8]([C:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][C:14]([OH:24])=[CH:15][C:16]=3[OH:20])[O:11][C:10]=2[CH2:28][Br:29])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 155987304',5,7-Triacetoxy-2-bromomethylisoflavone

Product 1

HCID 155987314',5,7-Trihydroxy-2-bromomethylisoflavoneYield 94.3%

Conditions

Temperature
100 °C

Procedure

A mixture of 4',5,7-triacetoxy-2-bromomethylisoflavone (1 g) and 48% hydrobromic acid (7 ml) was heated at 100° C. for one hour, the reaction mixture was cooled with stirring, and the solid which separated out was collected by filtration and washed with water, giving 0.7 g of 4',5,7-trihydroxy-2-bromomethylisoflavone.

Workup

  1. temperaturethe reaction mixture was cooled
  2. customthe solid which separated out
  3. filtrationwas collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-9c454452f3c24f6292c8f35a12eccc2f
Source dataset
uspto-grants-1990_10
Patent number
US04960908

Reaction notes

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