HCID 178478919, compound → HCID 178478918, compound

HRID 1088045Notes

Reaction equation

HRID 1088045 reaction equation
I.[ClH:2].[NH2:3][C@@H:4]1[C:21](=[O:22])[N:6]2[C:7]([C:18]([O-:20])=[O:19])=[C:8]([CH2:11][N+:12]3[N:13]([CH3:17])[CH:14]=[CH:15][CH:16]=3)[CH2:9][S:10][C@H:5]12>O.CC(C)=O>[ClH:2].[NH2:3][C@@H:4]1[C:21](=[O:22])[N:6]2[C:7]([C:18]([O-:20])=[O:19])=[C:8]([CH2:11][N+:12]3[N:13]([CH3:17])[CH:14]=[CH:15][CH:16]=3)[CH2:9][S:10][C@H:5]12

Participants

4

Reactant 1

HCID 178478919HCID 178478919, compound

Product 1

HCID 178478918HCID 178478918, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A mixture of 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride hydroiodide (10 g) in water (70 ml) and acetone (130 ml) was stirred at 0°-5° C. for 1.5 hours. The precipitates crystallized out of the solution were collected by filtration, washed with a mixture of acetone (24 ml) and water (6 ml) and then acetone to give 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride.tetrahydrate (6.6 g).

Workup

  1. customThe precipitates crystallized out of the solution
  2. filtrationwere collected by filtration
  3. washwashed with a mixture of acetone (24 ml) and water (6 ml)

Sources & evidence

ORD record
ord-18defd935e9c4e0cbff67774e69e0f3f
Source dataset
uspto-grants-1990_10
Patent number
US04960766

Reaction notes

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