HCID 178478919, compound → HCID 178478918, compound

Participants

Reaction Steps

A mixture of 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride hydroiodide (10 g) in water (70 ml) and acetone (130 ml) was stirred at 0°-5° C. for 1.5 hours. The precipitates crystallized out of the solution were collected by filtration, washed with a mixture of acetone (24 ml) and water (6 ml) and then acetone to give 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride.tetrahydrate (6.6 g).

Provenance & Evidence