Trifluoroacetic acid → HCID 178428555, compound

HRID 1088054Notes

Reaction equation

FC(F)(F)C(O)=O.FC(F)ON=C(C1N=C(NC(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)SC=1)C(N[C@@H:16]1[C:34](=[O:35])[N:18]2[C:19]([C:31]([O-:33])=[O:32])=[C:20]([CH2:23][N+:24]3[N:25]([CH3:30])[CH:26]=[CH:27][C:28]=3[CH3:29])[CH2:21][S:22][C@H:17]12)=O>>[CH3:30][N:25]1[CH:26]=[CH:27][C:28]([CH3:29])=[N+:24]1[CH2:23][C:20]1[CH2:21][S:22][C@@H:17]2[CH2:16][C:34](=[O:35])[N:18]2[C:19]=1[C:31]([O-:33])=[O:32]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178428556HCID 178428556, compound

Product 1

HCID 178428555HCID 178428555, compound

Procedure

7β-[2-(2-Aminothiazol-4-yl)-2-difluoromethoxyimino)acetamido]- 3-(2,5-dimethyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer) was prepared from trifluoroacetic acid salt of 7β-[2-difluoromethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(2,5-dimethyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer) according to a similar manner to that of Example 29.

Sources & evidence

ORD record: ord-94bad1d8552c49ada0f55aadb5a32579
Source dataset: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04960766

Reaction notes

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