Sulfuric Acid → HCID 178480385, compound

HRID 1088064Notes

Reaction equation

HRID 1088064 reaction equation
C(=O)([O-])[O-:2].[Na+].[Na+].S(=O)(=O)(O)[OH:8].[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18](=[N:41][O:42][CH:43]([F:45])[F:44])[C:19]([NH:21][C@@H:22]2[C:39](=[O:40])[N:24]3[C:25]([C:36]([O-:38])=[O:37])=[C:26]([CH2:29][N+:30]4[N:31]([CH3:35])[CH:32]=[CH:33][CH:34]=4)[CH2:27][S:28][C@H:23]23)=[O:20])[N:17]=1>O>[OH2:2].[OH2:8].[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18](=[N:41][O:42][CH:43]([F:44])[F:45])[C:19]([NH:21][C@@H:22]2[C:39](=[O:40])[N:24]3[C:25]([C:36]([O-:38])=[O:37])=[C:26]([CH2:29][N+:30]4[N:31]([CH3:35])[CH:32]=[CH:33][CH:34]=4)[CH2:27][S:28][C@H:23]23)=[O:20])[N:17]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 178480384HCID 178480384, compound

Product 1

HCID 178480385HCID 178480385, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium carbonate (6.06 g) was added to a suspension of sulfuric acid salt of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer)(35 g) in water (105 ml) and then the solution was allowed to stand at 3° to 5° C. for 14 hours. The resultant precipitates were collected by filtration, washed with cool water (50 ml) and dried to give crystals of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate dihydrate (syn isomer) (23.8 g).

Workup

  1. customThe resultant precipitates
  2. filtrationwere collected by filtration
  3. washwashed with cool water (50 ml)
  4. customdried

Sources & evidence

ORD record
ord-c597e426c9db44db83a703a2f35d330d
Source dataset
uspto-grants-1990_10
Patent number
US04960766

Reaction notes

Loading…