huagongshe.com
HRID1088064

反应详情

EQUATION

反应方程式

HRID 1088064 的结构方程式

REACTANTS

反应物

3
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：Cn1ccc[n+]1CC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)C(=NOC(F)F)c3csc(N)n3)[C@H]2SC1
HCID178480384

未命名化合物

PRODUCTS

生成物

1
结构：Cn1ccc[n+]1CC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)C(=NOC(F)F)c3csc(N)n3)[C@H]2SC1.O.O
HCID178480385

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Sodium carbonate (6.06 g) was added to a suspension of sulfuric acid salt of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer)(35 g) in water (105 ml) and then the solution was allowed to stand at 3° to 5° C. for 14 hours. The resultant precipitates were collected by filtration, washed with cool water (50 ml) and dried to give crystals of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate dihydrate (syn isomer) (23.8 g).

WORKUP

后处理

  1. customThe resultant precipitates
  2. filtrationwere collected by filtration
  3. washwashed with cool water (50 ml)
  4. customdried