Sulfuric Acid → HCID 178480385, compound

Participants

Reaction Steps

Sodium carbonate (6.06 g) was added to a suspension of sulfuric acid salt of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer)(35 g) in water (105 ml) and then the solution was allowed to stand at 3° to 5° C. for 14 hours. The resultant precipitates were collected by filtration, washed with cool water (50 ml) and dried to give crystals of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate dihydrate (syn isomer) (23.8 g).

Provenance & Evidence