Pyridine → HCID 70362191, compound

HRID 1088237Notes

Reaction equation

HRID 1088237 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](Cl)=[O:8].N1C=CC=CC=1.[C:16]1([C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:8])=[O:28].[C:16]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 71034-HydroxybiphenylHCID 88279Pyrazinecarbonyl chloride

Product 1

HCID 70362191HCID 70362191, compoundYield 45.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 3.5 g (25 mmol) of pyrazinoyl chloride dissolved in methylene chloride (20 mL) and pyridine (2 mL) cooled to 0° C. in a 50 mL round bottom flask was added 4-phenyl-phenol (5.0 g, 30 mmol). Upon completion of the reaction and isolation as described above recrystallization from hexanes yielded 3.15 g (39% yield) of the crystalline title compound; m.p: 95°-98° C. Elemental Analysis: C17H12N2O2Calcd: C:73.90, H:4.38. Found: C:73.68, H:4.28.

Workup

  1. customUpon completion of the reaction and isolation
  2. customas described above recrystallization from hexanes

Sources & evidence

ORD record
ord-2a46911750a842c1864f11d897b15d97
Source dataset
uspto-grants-1990_10
Patent number
US04962111

Reaction notes

Loading…