1-Propanol → Propyl pyrazinoate

HRID 1088238Notes

Reaction equation

HRID 1088238 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](Cl)=[O:8].N1C=C[CH:13]=[CH:12][CH:11]=1.C([OH:19])CC>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:8][CH2:11][CH2:12][CH3:13])=[O:19]

Participants

5

Reactant 3

HCID 10311-PropanolHCID 1049PyridineHCID 88279Pyrazinecarbonyl chloride

Product 1

HCID 72507Propyl pyrazinoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4.0 g (28 mmol) of pyrazinoyl chloride dissolved in methylene chloride (20 mL) and pyridine (2 mL) cooled to 0° C. in a 50 mL round bottom flask was added n-propyl alcohol (4.0 g, 66 mmol). Completion of the reaction and separation as described above, followed by distillation, led to isolation of the title compound as a water white oil; b.p: 68°-73° C. at 0.20 mm Hg.

Workup

  1. customCompletion of the reaction and separation
  2. distillationfollowed by distillation

Sources & evidence

ORD record
ord-5e35d677b44e4426bd94407fb40b664c
Source dataset
uspto-grants-1990_10
Patent number
US04962111

Reaction notes

Loading…