反应详情

A solution of sodium methoxide (0.9 g) in ethanol (5 cm3) was added dropwise to a stirred suspension of guanidine hydrochloride (1.58 g) and ethyl (RS)-4-dimethylamino-3-formyl-2-(1-methylethyl)-3-butenoate in ethanol (10 cm3). The reaction mixture was heated at the reflux temperature for 2 hours, then stood at the ambient temperature for 70 hours. The solvent was evaporated under reduced pressure and water added to the residue.

1. temperatureThe reaction mixture was heated at the reflux temperature for 2 hours
2. customThe solvent was evaporated under reduced pressure and water
3. additionadded to the residue